InhaltsangabePart I. Introduction to Drug-Drug Interactions1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions F. Jacob Seagull, PhD, Catherine Marcucci, MD2. Pharmacodynamic Interactions: Core ConceptsErica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc3. Pharmacokinetic Interactions: Core ConceptsErica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 4. A Brief Treatise On The Area Under The CurveMichael J. Sikora, MD, Barbara Jericho, MDPart II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters5. CYP2D6: Where It All BeganJohn C. Sanders, MBBS, FRCA, Rachel Koll, MD, Randal O. Dull, MD, PhD 6. CYP2E1: The Anesthesia EnzymeBenjamin S. Gmelch, MD, Randal O. Dull, MD, PhD7. CYP3A4: The WorkhorseJennifer DeCou, MD, Nathaniel Birgenheier, MD, Randal O. Dull, MD, PhD8. CYP1A2: The Switch-hitterDanielle Roussel, MD, Emily Hagn, MD, Randal O. Dull, MD, PhD9. CYP2B: 2B or Not 2B?Dustin Coyle, MD, Randal O. Dull, MD, PhD10. CYP2C9: The Support Crew IByron Douglas Fergerson, MD, Crystal B. Wallentine, MD, Randal O. Dull, MD, PhD11. CYP2C19: The Support Crew IIBarbara Jericho, MD, Alfredo Aguiar, MD, Randal O. Dull, MD, PhD12. UGTs: Conjugating CousinsNeil B. Sandson, MD13. The Cytochrome P450 System In Disease States-A Brief ReviewCatherine Marcucci, MDPART III. Drug-Drug Interactions: Paradigms and Core Concepts14. P-glycoprotein and OATP TransportersDustin Coyle MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD15. The "Fatal" FortyNeil B. Sandson MD, Michael Hutchens MD, F. Jacob Seagull, PhD, Catherine Marcucci, MD16. The Six Patterns of Pharmacokinetic Drug-Drug InteractionsNeil B. Sandson, MD, Catherine Marcucci, MD17. The Problem with the Drug-Drug Interaction Software: A Procrustean DilemmaNeil B. Sandson, MD, F. Jacob Seagull, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD 18. PharmacogenomicsChad D. Moore, PhD, William Hartman, MD, PhD, Michael Hutchens, MD, Randal O. Dull, MD, PhD19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are ImportantJoseph A. Lovely, PharmD, BCPS, Stephen Esper, MD, MBA, Michael Hutchens, MD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD 20. The Lawyers Can Read, Too: Case Presentations from the CourtroomJessica Voge, MD, David K. Miller, JDPart IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents21. IntroductionCatherine Marcucci, MD22. That Sums It Up Volatile anesthetics, additive MACs James A. Jernigan, MD, James W. Ibinson, MD, PhD23. 1+1+1+1=? Variable effects of combined substancesAnthony T. Silipo, DO, Raymond M. Planinsic, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung MD,PhD, Wayne T. Nicholson, MD, PharmD, MSc24. A Delayed Surgeon Is A "Dismayed" Surgeon? Nitrous oxide, dexmedetomidine, somatosensory evoked potentialsJonathan Anson, MD25. Relax, It's Only Gentamicin Volatile anesthetics, aminoglycoside antibiotics, neuromuscular junctionBrian Gierl, MD, Ferenc E. Gyulai, MD26. Jaundice After Surgery Halothane hepatitis, CYP2E1Jonathon E. Kivela, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD27. Everybody Clear? Halothane, epinephrine arrhythmiaNikhli Patel, MD, Barbara Jericho MD, Randal O. Dull, MD, PhD28. The Hemodynamic Hole general anesthetics, ACE-I, ARBsArun L. Jayaraman, MD, PhD, Theresa A. Gelzinis, MD29. Alpha-2 To The Rescue But Beware Bradycardia volatile anesthetics, alpha-2 agents